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Duloxetine is used to treat depression and anxiety.

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A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants (''mood elevators'') such as duloxetine during clinical studies became suicidal (thinking about harming or ing oneself or planning or trying to do so).

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Bupropion acts as an norepinephrine-dopamine reuptake inhibitor (NDRI).

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